1. Zhou Xiaojuan., Li Ang., Mi Xue., Li Yixuan., Ding Zhaoyi., An Min., Chen Yalan., Li Wei., Tao Xianming., Chen Xinfeng., Li Ying.(2023). Hyperexcited limbic neurons represent sexual satiety and reduce mating motivation. Science, 379(6634), 820-825. (20230209,北京脑科学与类脑研究中心,李莹)
2. Lin Jianwei., Wu Yiping., Tian Gaofei., Yu Daqi., Yang Eunjeong., Lam Wai Hei., Liu Zheng., Jing Yihang., Dang Shangyu., Bao Xiucong., Wong Jason Wing Hon., Zhai Yuanliang., Li Xiang David.(2023). Menin "reads" H3K79me2 mark in a nucleosomal context. Science, 379(6633), 717-723.(20230216,香港大学,李祥、翟元樑、黃永瀚、鲍秀丛)
3. Qin Tao., Zhang Guokun., Zheng Yi., Li Shengyou., Yuan Yuan., Li Qingjie., Hu Mingliang., Si Huazhe., Wei Guanning., Gao Xueli., Cui Xinxin., Xia Bing., Ren Jing., Wang Kun., Ba Hengxing., Liu Zhen., Heller Rasmus., Li Zhipeng., Wang Wen., Huang Jinghui., Li Chunyi., Qiu Qiang.(2023). A population of stem cells with strong regenerative potential discovered in deer antlers. Science, 379(6634), 840-847.(20230223,西北工业大学,邱强、王文;空军军医大学西京医院,黄景辉;长春科技学院,李春义;吉林农业大学,李志鹏)
5. Mao Chunyou., Xiao Peng., Tao Xiao-Na., Qin Jiao., He Qing-Tao., Zhang Chao., Guo Sheng-Chao., Du Ya-Qin., Chen Li-Nan., Shen Dan-Dan., Yang Zhi-Shuai., Zhang Han-Qiong., Huang Shen-Ming., He Yong-Hao., Cheng Jie., Zhong Ya-Ni., Shang Pan., Chen Jun., Zhang Dao-Lai., Wang Qian-Lang., Liu Mei-Xia., Li Guo-Yu., Guo Yongyuan., Xu H Eric., Wang Chuanxin., Zhang Cheng., Feng Shiqing., Yu Xiao., Zhang Yan., Sun Jin-Peng.(2023). Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380(6640), eadd6220.(20230302,山东大学,孙金鹏、冯世庆、于晓;浙江大学,张岩)
6. Dong Shihao., Lin Tao., Nieh James C., Tan Ken.(2023). Social signal learning of the waggle dance in honey bees. Science, 379(6636), 1015-1018.(20230309,中国科学院西双版纳热带植物园,谭垦;加州大学圣地亚哥分校,James C. Nieh)
7. Xie Guohui., Du Xuan., Hu Hongmiao., Li Sisi., Cao Xiaofeng., Jacobsen Steven E., Du Jiamu.(2023). Structure and mechanism of the plant RNA polymerase V. Science, 379(6638), 1209-1213.(20230309,南方科技大学,杜嘉木)
10. Tu Hai-Qing., Li Sen., Xu Yu-Ling., Zhang Yu-Cheng., Li Pei-Yao., Liang Li-Yun., Song Guang-Ping., Jian Xiao-Xiao., Wu Min., Song Zeng-Qing., Li Ting-Ting., Hu Huai-Bin., Yuan Jin-Feng., Shen Xiao-Lin., Li Jia-Ning., Han Qiu-Ying., Wang Kai., Zhang Tao., Zhou Tao., Li Ai-Ling., Zhang Xue-Min., Li Hui-Yan.(2023). Rhythmic cilia changes support SCN neuron coherence in circadian clock. Science, 380(6648), 972-979. (20230601,军事科学院军事医学研究院,李慧艳、张学敏)
11. Shao Yong., Zhou Long., Li Fang., Zhao Lan., Zhang Bao-Lin., Shao Feng., Chen Jia-Wei., Chen Chun-Yan., Bi Xupeng., Zhuang Xiao-Lin., Zhu Hong-Liang., Hu Jiang., Sun Zongyi., Li Xin., Wang Depeng., Rivas-González Iker., Wang Sheng., Wang Yun-Mei., Chen Wu., Li Gang., Lu Hui-Meng., Liu Yang., Kuderna Lukas F K., Farh Kyle Kai-How., Fan Peng-Fei., Yu Li., Li Ming., Liu Zhi-Jin., Tiley George P., Yoder Anne D., Roos Christian., Hayakawa Takashi., Marques-Bonet Tomas., Rogers Jeffrey., Stenson Peter D., Cooper David N., Schierup Mikkel Heide., Yao Yong-Gang., Zhang Ya-Ping., Wang Wen., Qi Xiao-Guang., Zhang Guojie., Wu Dong-Dong.(2023). Phylogenomic analyses provide insights into primate evolution. Science, 380(6648), 913-924.(20230601,昆明动物所,吴东东;浙江大学,张国捷;西北大学,齐晓光)
13. Wu Hong., Wang Zefu., Zhang Yuxing., Frantz Laurent., Roos Christian., Irwin David M., Zhang Chenglin., Liu Xuefeng., Wu Dongdong., Huang Song., Gu Tongtong., Liu Jianquan., Yu Li.(2023). Hybrid origin of a primate, the gray snub-nosed monkey. Science, 380(6648), eabl4997.(20230602,云南大学,于黎;四川大学,刘健全)
14. Qi Xiao-Guang., Wu Jinwei., Zhao Lan., Wang Lu., Guang Xuanmin., Garber Paul A., Opie Christopher., Yuan Yuan., Diao Runjie., Li Gang., Wang Kun., Pan Ruliang., Ji Weihong., Sun Hailu., Huang Zhi-Pang., Xu Chunzhong., Witarto Arief B., Jia Rui., Zhang Chi., Deng Cheng., Qiu Qiang., Zhang Guojie., Grueter Cyril C., Wu Dongdong., Li Baoguo.(2023). Adaptations to a cold climate promoted social evolution in Asian colobine primates. Science, 380(6648), eabl8621.(20230602,西北大学,李保国)
15. Liu Zhiyuan., Chen Yujie., Xia Qimin., Liu Menghan., Xu Heming., Chi Yi., Deng Yujing., Xing Dong.(2023). Linking genome structures to functions by simultaneous single-cell Hi-C and RNA-seq. Science, 380(6649), 1070-1076.(20230608,北京大学生物医学前沿创新中心,邢栋)
16. Zhang Tao., Xu Daichao., Trefts Elijah., Lv Mingming., Inuzuka Hiroyuki., Song Guobin., Liu Min., Lu Jianlin., Liu Jianping., Chu Chen., Wang Min., Wang Huibing., Meng Huyan., Liu Hui., Zhuang Yuan., Xie Xingxing., Dang Fabin., Guan Dongxian., Men Yuqin., Jiang Shuwen., Jiang Cong., Dai Xiaoming., Liu Jing., Wang Zhen., Yan Peiqiang., Wang Jingchao., Tu Zhenbo., Babuta Mrigya., Erickson Emily., Hillis Alissandra L., Dibble Christian C., Asara John M., Szabo Gyongy., Sicinski Piotr., Miao Ji., Lee Yu-Ru., Pan Lifeng., Shaw Reuben J., Yuan Junying., Wei Wenyi.(2023). Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. Science, 380(6652), 1372-1380. (20230629,哈佛医学院,魏文毅;中科院生物与化学交叉研究中心,袁钧瑛;索尔克生物研究所,Reuben Shaw;中科院上海有机化学研究所,潘李峰;中科院生物与化学交叉研究中心,许代超)
17. Huang Fei., Luo Xiao., Ou Yang., Gao Zhaoxu., Tang Qiming., Chu Zhenzhen., Zhu Xinguang., He Yuehui.(2023). Control of histone demethylation by nuclear-localized α-ketoglutarate dehydrogenase. Science, 381(6654), eadf8822.(20230714,北京大学,何跃辉)
18. Wang Kai., Zhang Zhiwei., Hang Jing., Liu Jia., Guo Fusheng., Ding Yong., Li Meng., Nie Qixing., Lin Jun., Zhuo Yingying., Sun Lulu., Luo Xi., Zhong Qihang., Ye Chuan., Yun Chuyu., Zhang Yi., Wang Jue., Bao Rui., Pang Yanli., Wang Guang., Gonzalez Frank J., Lei Xiaoguang., Qiao Jie., Jiang Changtao.(2023). Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target. Science, 381(6657), eadd5787. (20230804,北京大学医学部基础医学院/北京大学第三医院医学创新研究院,姜长涛;北京大学第三医院,乔杰;北京大学,雷晓光;美国国立卫生研究院,Frank Gonzalez;首都医科大学朝阳医院,王广)
19. Zhou Zijing., Ma Xiaonuo., Lin Yiechang., Cheng Delfine., Bavi Navid., Secker Genevieve A., Li Jinyuan Vero., Janbandhu Vaibhao., Sutton Drew L., Scott Hamish S., Yao Mingxi., Harvey Richard P., Harvey Natasha L., Corry Ben., Zhang Yixiao., Cox Charles D.(2023). MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels. Science, 381(6659), 799-804.(20230818,澳大利亚Victor Chang心脏研究所,Charles Cox;中科院上海有机化学研究所生物与化学交叉中心,张一小)
20. Wang Yuhao., Wang Meng., Chen Jiaxin., Li Yun., Kuang Zheng., Dende Chaitanya., Raj Prithvi., Quinn Gabriella., Hu Zehan., Srinivasan Tarun., Hassell Brian., Ruhn Kelly A., Behrendt Cassie L., Liang Tingbo., Dou Xiaobing., Song Zhangfa., Hooper Lora V.(2023). Snhg9The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA . Science, 381(6660), 851-857.(20230825,美国西南医学中心,Lora Hooper;浙江大学,王宇浩)
22. Hu Wangjie., Hao Ziqian., Du Pengyuan., Di Vincenzo Fabio., Manzi Giorgio., Cui Jialong., Fu Yun-Xin., Pan Yi-Hsuan., Li Haipeng.(2023). Genomic inference of a severe human bottleneck during the Early to Middle Pleistocene transition.Science, 381(6661), 979-984.(20230831,中国科学院上海营养与健康研究所,李海鹏;华东师范大学,潘逸萱)
23. Li Yu., Liu Shaorui., Zhou Kewen., Wang Yinsheng., Chen Yan., Hu Wen., Li Shuyan., Li Hui., Wang Yan., Wang Qiuying., He Danyang., Xu Heping.(2023). Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine. Science, 381(6663), 1189-1196.(20230914,西湖大学,徐和平)
24. Jiang Yanyou., Cao Tianjun., Yang Yuqing., Zhang Huan., Zhang Jingyu., Li Xiaobo.(2023). A chlorophyll synthase widely co-opted by phytoplankton. Science, 382(6666), 92-98.(20231005,西湖大学,李小波)
26. Yang Ning., Wang Yuebin., Liu Xiangguo., Jin Minliang., Vallebueno-Estrada Miguel., Calfee Erin., Chen Lu., Dilkes Brian P., Gui Songtao., Fan Xingming., Harper Thomas K., Kennett Douglas J., Li Wenqiang., Lu Yanli., Ding Junqiang., Chen Ziqi., Luo Jingyun., Mambakkam Sowmya., Menon Mitra., Snodgrass Samantha., Veller Carl., Wu Shenshen., Wu Siying., Zhuo Lin., Xiao Yingjie., Yang Xiaohong., Stitzer Michelle C., Runcie Daniel., Yan Jianbing., Ross-Ibarra Jeffrey.(2023). Two teosintes made modern maize. Science, 382(6674), eadg8940.(20231201,华中农业大学,杨宁、严建兵;美国加州大学戴维斯分校,Jeffrey Ross-Ibarra)
27. Yan Pengshuai., Du Qingguo., Chen Huan., Guo Zifeng., Wang Zhonghua., Tang Jihua., Li Wen-Xue.(2023). Biofortification of iron content by regulating a NAC transcription factor in maize. Science, 382(6675), 1159-1165.(20231207,中国农科院作科所,李文学;河南农业大学,汤继华)
28. Li Lijia., Lai Fangnong., Hu Xiaoyu., Liu Bofeng., Lu Xukun., Lin Zili., Liu Ling., Xiang Yunlong., Frum Tristan., Halbisen Michael A., Chen Fengling., Fan Qiang., Ralston Amy., Xie Wei.(2023). Multifaceted SOX2-chromatin interaction underpins pluripotency progression in early embryos. Science, 382(6676), eadi5516.(20231215,清华大学,颉伟)
29. Chen Xizi., Liu Weida., Wang Qianmin., Wang Xinxin., Ren Yulei., Qu Xuechun., Li Wanjun., Xu Yanhui.(2023). Structural visualization of transcription initiation in action. Science, 382(6677), eadi5120.(20231222,复旦大学,徐彦辉)
该项研究首次用结构重现出了转录从头起始的16个连续动态全过程,揭示了通用转录因子(GTFs)和转录泡协同RNA聚合酶Pol II调控转录起始向转录延伸转变的分子机制。(Science专家点评丨玉汝于成,功不唐捐——徐彦辉团队揭示转录起始连续动态全过程)30.Sang, Q., P. F. Ray and L. Wang* (2023). Understanding the genetics of human infertility. Science 380(6641): 158-163.(20230413,复旦大学,王磊,特邀综述)(Science生殖专刊丨王磊/桑庆受邀撰写不孕不育遗传学研究综述) 2023年Nature(研究性文章50篇,1篇古生物学论文)1. You Linlin., Omollo Expery O., Yu Chengzhi., Mooney Rachel A., Shi Jing., Shen Liqiang., Wu Xiaoxian., Wen Aijia., He Dingwei., Zeng Yuan., Feng Yu., Landick Robert., Zhang Yu.(2023). Structural basis for intrinsic transcription termination. Nature, 613(7945), 783-789.(20230111,国科学院分子植物科学卓越创新中心,张余;美国威斯康辛大学麦迪逊分校,Robert Landick;浙江大学,冯钰)
2. Huang Jiabao., Yang Lin., Yang Liu., Wu Xiaoyu., Cui Xiaoshuang., Zhang Lili., Hui Jiyun., Zhao Yumei., Yang Hongmin., Liu Shangjia., Xu Quanling., Pang Maoxuan., Guo Xinping., Cao Yunyun., Chen Yu., Ren Xinru., Lv Jinzhi., Yu Jianqiang., Ding Junyi., Xu Gang., Wang Nian., Wei Xiaochun., Lin Qinghui., Yuan Yuxiang., Zhang Xiaowei., Ma Chaozhi., Dai Cheng., Wang Pengwei., Wang Yongchao., Cheng Fei., Zeng Weiqing., Palanivelu Ravishankar., Wu Hen-Ming., Zhang Xiansheng., Cheung Alice Y., Duan Qiaohong.(2023). Stigma receptors control intraspecies and interspecies barriers in Brassicaceae. Nature, 614(7947), 303-308. (20230125,山东农业大学,段巧红;马萨诸塞大学,Alice Y. Cheung)
3. Liu Hao., Li Anjie., Rochaix Jean-David., Liu Zhenfeng.(2023). Architecture of chloroplast TOC-TIC translocon supercomplex. Nature, 615(7951), 349-357.(20230126,中国科学院生物物理研究所,柳振峰)
4. Shan Lin., Xu Guang., Yao Run-Wen., Luan Peng-Fei., Huang Youkui., Zhang Pei-Hong., Pan Yu-Hang., Zhang Lin., Gao Xiang., Li Ying., Cao Shi-Meng., Gao Shuai-Xin., Yang Zheng-Hu., Li Siqi., Yang Liang-Zhong., Wang Ying., Wong Catharine C L., Yu Li., Li Jinsong., Yang Li., Chen Ling-Ling.(2023). Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance. Nature, 615(7952), 526-534.(20230308,中国科学院分子细胞科学卓越创新中心,陈玲玲)
5. Yang Jie., Lan Tian., Zhang Xi-Guang., Smith Martin R.(2023). Protomelission is an early dasyclad alga and not a Cambrian bryozoan. Nature, 615(7952), 468-471.(20230308,云南大学,张喜光;英国杜伦大学,Martin Smith)
研究结果表明目前尚未发现明确的寒武纪时期的苔藓动物化石。
6. You Xin., Zhang Xing., Cheng Jing., Xiao Yanan., Ma Jianfei., Sun Shan., Zhang Xinzheng., Wang Hong-Wei., Sui Sen-Fang.(2023). In situ structure of the red algal phycobilisome-PSII-PSI-LHC megacomplex. Nature, 616(7955), 199-206.(20230315,清华大学,隋森芳、王宏伟;中科院生物物理研究所,章新政)
7. Hu Xinlin., Yang Ping., Chai Changdong., Liu Jia., Sun Huanhuan., Wu Yanan., Zhang Mingjie., Zhang Min., Liu Xiaotian., Yu Hongjun.(2023). Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1. Nature, 616(7955), 190-198.(20230322,华中科技大学同济基础医学院,于洪军、张敏;南方科技大学生命科学院,刘晓天)
8. Li Yaxin., Shen Hao., Zhang Ruixue., Ji Chenggong., Wang Yuxin., Su Chen., Xiao Junyu.(2023). Immunoglobulin M perception by FcμR. Nature, 615(7954), 907-912.(20230322,北京大学,肖俊宇)
9. Ge Weiran., Yu Cong., Li Jingjing., Yu Zhenyu., Li Xiaorong., Zhang Yan., Liu Chao-Pei., Li Yingfeng., Tian Changlin., Zhang Xinzheng., Li Guohong., Zhu Bing., Xu Rui-Ming.(2023). Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase. Nature, 616(7955).(20230329,中国科学院生物物理研究所,许瑞明、朱冰)
11. Liu William J., Liu Peipei., Lei Wenwen., Jia Zhiyuan., He Xiaozhou., Shi Weifeng., Tan Yun., Zou Shumei., Wong Gary., Wang Ji., Wang Feng., Wang Gang., Qin Kun., Gao Rongbao., Zhang Jie., Li Min., Xiao Wenling., Guo Yuanyuan., Xu Ziqian., Zhao Yingze., Song Jingdong., Zhang Jing., Zhen Wei., Zhou Wenting., Ye Beiwei., Song Juan., Yang Mengjie., Zhou Weimin., Dai Yuting., Lu Gang., Bi Yuhai., Tan Wenjie., Han Jun., Gao George F., Wu Guizhen.(2023). Surveillance of SARS-CoV-2 at the Huanan Seafood Market. Nature.(20230405,中国疾病预防控制中心病毒病预防控制所,武桂珍、高福、刘军)
12. Song Long., Liu Jie., Cao Beilu., Liu Bin., Zhang Xiaoping., Chen Zhaoyan., Dong Chaoqun., Liu Xiangqing., Zhang Zhaoheng., Wang Wenxi., Chai Lingling., Liu Jing., Zhu Jun., Cui Shubin., He Fei., Peng Huiru., Hu Zhaorong., Su Zhenqi., Guo Weilong., Xin Mingming., Yao Yingyin., Yan Yong., Song Yinming., Bai Guihua., Sun Qixin., Ni Zhongfu.(2023). Reducing brassinosteroid signalling enhances grain yield in semi-dwarf wheat. Nature, 617(7959), 118-124.(20230426,中国农业大学,倪中福)
14. Zhang He., Zhang Liang., Lin Ang., Xu Congcong., Li Ziyu., Liu Kaibo., Liu Boxiang., Ma Xiaopin., Zhao Fanfan., Jiang Huiling., Chen Chunxiu., Shen Haifa., Li Hangwen., Mathews David H., Zhang Yujian., Huang Liang.(2023). Algorithm for optimized mRNA design improves stability and immunogenicity.Nature, 621(7978), 396-403.(20230502,百度美国研究院,Liang Huang;斯微(上海)生物科技股份有限公司,Yujian Zhang、Hangwen Li;罗切斯特大学,David H. Mathews)
15. Guo Lulu., Cheng Jie., Lian Shuo., Liu Qun., Lu Yan., Zheng Yuan., Zhu Kongkai., Zhang Minghui., Kong Yalei., Zhang Chao., Rong Naikang., Zhuang Yuming., Fang Guoxing., Jiang Jingjing., Zhang Tianyao., Han Xiang., Liu Zili., Xia Ming., Liu Shangming., Zhang Lei., Liberles Stephen D., Yu Xiao., Xu Yunfei., Yang Fan., Li Qian., Sun Jin-Peng.(2023). Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618(7963), 193-200.(20230524,山东大学/北京大学,孙金鹏;上海交通大学医学院,李乾)
16. Li Zongqiang., Chen Shuaijiabin., Zhao Liang., Huang Guoqiang., Xu Huiqin., Yang Xiaoyun., Wang Peiyi., Gao Ning., Sui Sen-Fang.(2023). Nuclear export of pre-60S particles through the nuclear pore complex. Nature, 618(7964), 411-418.(20230531,清华大学/南方科技大学,隋森芳)
17. Chen Lingfeng., Fu Lili., Sun Jingchuan., Huang Zhiqiang., Fang Mingzhen., Zinkle Allen., Liu Xin., Lu Junliang., Pan Zixiang., Wang Yang., Liang Guang., Li Xiaokun., Chen Gaozhi., Mohammadi Moosa.(2023). Structural basis for FGF hormone signalling. Nature, 618(7966), 862-870.(20230607,温州医科大学,李校堃、陈高帜、穆萨·穆罕默迪)
20. Gao Yang., Yang Xiaofei., Chen Hao., Tan Xinjiang., Yang Zhaoqing., Deng Lian., Wang Baonan., Kong Shuang., Li Songyang., Cui Yuhang., Lei Chang., Wang Yimin., Pan Yuwen., Ma Sen., Sun Hao., Zhao Xiaohan., Shi Yingbing., Yang Ziyi., Wu Dongdong., Wu Shaoyuan., Zhao Xingming., Shi Binyin., Jin Li., Hu Zhibin., Chinese Pangenome Consortium (CPC)., Lu Yan., Chu Jiayou., Ye Kai., Xu Shuhua.(2023). A pangenome reference of 36 Chinese populations. Nature, 619(7968), 112-121.(20230614,复旦大学,徐书华、陆艳;西安交通大学,叶凯;中国医学科学院,褚嘉祐)
21. Kang Yunlu., Chen Lei.(2023). Structural basis for the binding of DNP and purine nucleotides onto UCP1. Nature, 620(7972), 226-231.(20230619,北京大学,陈雷)
23. Liang Liang., Cao Changchang., Ji Lei., Cai Zhaokui., Wang Di., Ye Rong., Chen Juan., Yu Xiaohua., Zhou Jie., Bai Zhibo., Wang Ruoyan., Yang Xianguang., Zhu Ping., Xue Yuanchao.(2023). Complementary Alu sequences mediate enhancer-promoter selectivity. Nature, 619(7971), 868-875.(20230712,中国科学院生物物理研究所,薛愿超)
24. Ji Shuyan., Chen Fengling., Stein Paula., Wang Jiacheng., Zhou Ziming., Wang Lijuan., Zhao Qing., Lin Zili., Liu Bofeng., Xu Kai., Lai Fangnong., Xiong Zhuqing., Hu Xiaoyu., Kong Tianxiang., Kong Feng., Huang Bo., Wang Qiujun., Xu Qianhua., Fan Qiang., Liu Ling., Williams Carmen J., Schultz Richard M., Xie Wei.(2023). OBOX regulates mouse zygotic genome activation and early development. Nature, 620(7976), 1047-1053.(20230717,清华大学,颉伟;宾夕法尼亚大学,Richard M. Schultz)
25. Guan Haipeng., Wang Pei., Zhang Pei., Ruan Chun., Ou Yutian., Peng Bo., Zheng Xiangdong., Lei Jianlin., Li Bing., Yan Chuangye., Li Haitao.(2023). Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S. Nature, 620(7974), 669-675.(20230719,清华大学,李海涛、闫创业)
26. Zhao Li-Hua., He Qian., Yuan Qingning., Gu Yimin., He Xinheng., Shan Hong., Li Junrui., Wang Kai., Li Yang., Hu Wen., Wu Kai., Shen Jianhua., Xu H Eric.(2023). Conserved class B GPCR activation by a biased intracellular agonist. Nature, 621(7979), 635-641.(20230731,中科院上海药物所,徐华强、赵丽华)
27. Duan Jia., Liu Heng., Zhao Fenghui., Yuan Qingning., Ji Yujie., Cai Xiaoqing., He Xinheng., Li Xinzhu., Li Junrui., Wu Kai., Gao Tianyu., Zhu Shengnan., Lin Shi., Wang Ming-Wei., Cheng Xi., Yin Wanchao., Jiang Yi., Yang Dehua., Xu H Eric.(2023). GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620(7974), 676-681.(20230802,中国科学院上海药物研究所,徐华强、段佳、杨德华)
28. Chen Kun., Zhang Chenhui., Lin Shuling., Yan Xinyu., Cai Heng., Yi Cuiying., Ma Limin., Chu Xiaojing., Liu Yuchen., Zhu Ya., Han Shuo., Zhao Qiang., Wu Beili.(2023). Tail engagement of arrestin at the glucagon receptor.Nature, 620(7975), 904-910.(20230809,中国科学院上海药物研究所,吴蓓丽、赵强)
30. Wang Chaoxiong., Zheng Xichen., Zhang Jinlan., Jiang Xiaoyi., Wang Jia., Li Yuwei., Li Xiaonan., Shen Guanghui., Peng Jiayin., Zheng Peixuan., Gu Yunqing., Chen Jiaojiao., Lin Moubin., Deng Changwen., Gao Hai., Lu Zhigang., Zhao Yun., Luo Min.(2023). CD300ld on neutrophils is required for tumour-driven immune suppression. Nature, 621(7980), 830-839.(20230906,复旦大学,罗敏、卢智刚、高海;中国科学院分子细胞科学卓越创新中心,赵允)
31. Yuan Linjie., Ma Xianqiang., Yang Yunyun., Qu Yingying., Li Xin., Zhu Xiaoyu., Ma Weiwei., Duan Jianxin., Xue Jing., Yang Haoyu., Huang Jian-Wen., Yi Simin., Zhang Mengting., Cai Ningning., Zhang Lin., Ding Qingyang., Lai Kecheng., Liu Chang., Zhang Lilan., Liu Xinyi., Yao Yirong., Zhou Shuqi., Li Xian., Shen Panpan., Chang Qing., Malwal Satish R., He Yuan., Li Wenqi., Chen Chunlai., Chen Chun-Chi., Oldfield Eric., Guo Rey-Ting., Zhang Yonghui.(2023). Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells. Nature, 621(7980), 840-848.(20230906,清华大学,张永辉;湖北大学,郭瑞庭)
32. Duan Yinkai., Zhou Hao., Liu Xiang., Iketani Sho., Lin Mengmeng., Zhang Xiaoyu., Bian Qucheng., Wang Haofeng., Sun Haoran., Hong Seo Jung., Culbertson Bruce., Mohri Hiroshi., Luck Maria I., Zhu Yan., Liu Xiaoce., Lu Yuchi., Yang Xiuna., Yang Kailin., Sabo Yosef., Chavez Alejandro., Goff Stephen P., Rao Zihe., Ho David D., Yang Haitao.(2023). Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622(7982), 376-382.(20230911,上海科技大学,杨海涛;哥伦比亚大学,何大一)
33. Peng Qi., Yuan Bin., Cheng Jinlong., Wang Min., Gao Siwei., Bai Suran., Zhao Xuejin., Qi Jianxun., Gao George F., Shi Yi.(2023). Molecular mechanism of de novo replication by the Ebola virus polymerase. Nature, 622(7983), 603-610.(20230912,中国科学院微生物研究所,施一、高福、齐建勋)
34. Gong Qian., Wang Yunjing., He Linfang., Huang Fan., Zhang Danfeng., Wang Yan., Wei Xiang., Han Meng., Deng Haiteng., Luo Lan., Cui Feng., Hong Yiguo., Liu Yule.(2023). Molecular basis of methyl-salicylate-mediated plant airborne defence. Nature, 622(7981), 139-148.(20230913,清华大学,刘玉乐)
36. Gao Xiaopan., Shang Kun., Zhu Kaixiang., Wang Linyue., Mu Zhixia., Fu Xingke., Yu Xia., Qin Bo., Zhu Hongtao., Ding Wei., Cui Sheng.(2023). Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute.Nature.(20231002,中国医学科学院病原生物学研究所,崔胜;中国科学院物理研究所,丁玮、朱洪涛)
37. Zhang Feng., Zhang Bo., Wang Yuying., Jiang Runmin., Liu Jin., Wei Yuexian., Gao Xinyue., Zhu Yichao., Wang Xinli., Sun Mao., Kang Junjun., Liu Yingying., You Guoxing., Wei Ding., Xin Jiajia., Bao Junxiang., Wang Meiqing., Gu Yu., Wang Zhe., Ye Jing., Guo Shuangping., Huang Hongyan., Sun Qiang.(2023). An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption.Nature, 622(7984), 834-841.(20231004,军事科学院军事医学研究院,孙强;空军军医大学,张丰)
38. Ma Shuangshuang., Chen Min., Jiang Yihao., Xiang Xinkuan., Wang Shiqi., Wu Zuohang., Li Shuo., Cui Yihui., Wang Junying., Zhu Yanqing., Zhang Yan., Ma Huan., Duan Shumin., Li Haohong., Yang Yan., Lingle Christopher J., Hu Hailan.(2023). Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb. Nature, 622(7984), 802-809.(20231018,浙江大学,胡海岚)
40. Xiao Na., Xu Shuang., Li Ze-Kai., Tang Min., Mao Renbo., Yang Tian., Ma Si-Xing., Wang Peng-Hao., Li Meng-Tong., Sunilkumar Ajay., Rouyer François., Cao Li-Hui., Luo Dong-Gen.(2023). A single photoreceptor splits perception and entrainment by cotransmission. Nature, 623(7987), 562-570.(20231025,北京大学,罗冬根)
41. Sun Shuhui., Li Jiaming., Wang Si., Li Jingyi., Ren Jie., Bao Zhaoshi., Sun Le., Ma Xibo., Zheng Fangshuo., Ma Shuai., Sun Liang., Wang Min., Yu Yan., Ma Miyang., Wang Qiaoran., Chen Zhiyuan., Ma He., Wang Xuebao., Wu Zeming., Zhang Hui., Yan Kaowen., Yang Yuanhan., Zhang Yixin., Zhang Sheng., Lei Jinghui., Teng Zhao-Qian., Liu Chang-Mei., Bai Ge., Wang Yan-Jiang., Li Jian., Wang Xiaoqun., Zhao Guoguang., Jiang Tao., Belmonte Juan Carlos Izpisua., Qu Jing., Zhang Weiqi., Liu Guang-Hui.(2023). CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord. Nature, 624(7992), 611-620.(20231031,中国科学院动物研究所,刘光慧、曲静;中国科学院北京基因组研究所,张维绮)
发现一群全新的在年老的灵长类动物的脊髓中特异存在的CHIT1阳性小胶质细胞亚型,并将其命名为AIMoN-CPM(Aging-Induced Motor Neuron toxic CHIT1-Positive Microglia),这类细胞可以通过旁分泌CHIT1蛋白激活运动神经元中的SMAD信号,进而驱动运动神经元衰老,而补充维生素C可抑制脊髓运动神经元的衰老和退行。(专家点评Nature | 刘光慧/张维绮/曲静破解灵长类脊髓衰老驱动力)
42. Pidathala Shabareesh., Liao Shuyun., Dai Yaxin., Li Xiao., Long Changkun., Chang Chi-Lun., Zhang Zhe., Lee Chia-Hsueh.(2023). Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2. Nature, 623(7989), 1086-1092.(20231101,美国圣裘德儿童研究医院,李佳学;北京大学,张哲)
43. Xu Zheng., Guo Lulu., Yu Jingjing., Shen Siyuan., Wu Chao., Zhang Weifeng., Zhao Chang., Deng Yue., Tian Xiaowen., Feng Yuying., Hou Hanlin., Su Lantian., Wang Hongshuang., Guo Shuo., Wang Heli., Wang Kexin., Chen Peipei., Zhao Jie., Zhang Xiaoyu., Yong Xihao., Cheng Lin., Liu Lunxu., Yang Shengyong., Yang Fan., Wang Xiaohui., Yu Xiao., Xu Yunfei., Sun Jin-Peng., Yan Wei., Shao Zhenhua.(2023). Ligand recognition and G protein coupling of trace amine receptor TAAR1. Nature, 624(7992), 672-681.(20231107,四川大学,邵振华、颜微;山东大学,孙金鹏、于晓、徐云飞)
44. Liu Heng., Zheng You., Wang Yue., Wang Yumeng., He Xinheng., Xu Peiyu., Huang Sijie., Yuan Qingning., Zhang Xinyue., Wang Ling., Jiang Kexin., Chen Hong., Li Zhen., Liu Wenbin., Wang Sheng., Xu H Eric., Xu Fei.(2023). Recognition of methamphetamine and other amines by trace amine receptor TAAR1.Nature, 624(7992), 663-671.(20231107,上海科技大学,徐菲;中国科学院上海药物研究所,徐华强;中国科学院分子卓越创新中心,汪胜;上海市刑事科学技术研究院,刘文斌)
47. Zhang Bao., He Peng., Lawrence John E G., Wang Shuaiyu., Tuck Elizabeth., Williams Brian A., Roberts Kenny., Kleshchevnikov Vitalii., Mamanova Lira., Bolt Liam., Polanski Krzysztof., Li Tong., Elmentaite Rasa., Fasouli Eirini S., Prete Martin., He Xiaoling., Yayon Nadav., Fu Yixi., Yang Hao., Liang Chen., Zhang Hui., Blain Raphael., Chedotal Alain., FitzPatrick David R., Firth Helen., Dean Andrew., Bayraktar Omer Ali., Marioni John C., Barker Roger A., Storer Mekayla A., Wold Barbara J., Zhang Hongbo., Teichmann Sarah A.(2023). A human embryonic limb cell atlas resolved in space and time. Nature. (20231206,中山大学,张宏波;英国Sanger 研究所,Sarah Teichmann)
49. Wu Di., Chen Qihao., Yu Zhuoya., Huang Bo., Zhao Jun., Wang Yuhang., Su Jiawei., Zhou Feng., Yan Rui., Li Na., Zhao Yan., Jiang Daohua.(2023). Transport and inhibition mechanisms of human VMAT2. Nature.(20231211,中国科学院物理研究所/北京凝聚态物理国家研究中心,姜道华;中国科学院生物物理研究所,赵岩)
50. Ye Tong., Jiao Zhouguang., Li Xin., He Zhanlong., Li Yanyan., Yang Fengmei., Zhao Xin., Wang Youchun., Huang Weijin., Qin Meng., Feng Yingmei., Qiu Yefeng., Yang Wenhui., Hu Lingfei., Hu Yaling., Zhai Yu., Wang Erqiang., Yu Di., Wang Shuang., Yue Hua., Wang Yishu., Wang Hengliang., Zhu Li., Ma Guanghui., Wei Wei.(2023). Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization. Nature, 624(7992), 630-638.(20231213,中国科学院过程工程研究所,马光辉、魏炜;军事医学科学院生物工程研究所,朱力、王恒樑)
1. Li Jian., Dong Jiangqing., Wang Weitao., Yu Daqi., Fan Xinyu., Hui Yan Chit., Lee Clare S K., Lam Wai Hei., Alary Nathan., Yang Yang., Zhang Yingyi., Zhao Qian., Chen Chun-Long., Tye Bik-Kwoon., Dang Shangyu., Zhai Yuanliang.(2023). The human pre-replication complex is an open complex. Cell, 186(1), 98-111.e21.(20230105,香港大学,翟元梁;香港科技大学,党尚宇;香港科技大学/康奈尔大学,戴碧瓘;法国居里研究所,陈春龙)
2. Liu Xiaoqian., Liu Zunpeng., Wu Zeming., Ren Jie., Fan Yanling., Sun Liang., Cao Gang., Niu Yuyu., Zhang Baohu., Ji Qianzhao., Jiang Xiaoyu., Wang Cui., Wang Qiaoran., Ji Zhejun., Li Lanzhu., Esteban Concepcion Rodriguez., Yan Kaowen., Li Wei., Cai Yusheng., Wang Si., Zheng Aihua., Zhang Yong E., Tan Shengjun., Cai Yingao., Song Moshi., Lu Falong., Tang Fuchou., Ji Weizhi., Zhou Qi., Belmonte Juan Carlos Izpisua., Zhang Weiqi., Qu Jing., Liu Guang-Hui.(2023). Resurrection of endogenous retroviruses during aging reinforces senescence. Cell, 186(2), 287-304.e26.(20230106,中国科学院动物研究所,刘光慧、曲静;中国科学院北京基因组研究所,张维绮)
3. Wang Yue., Zhuang Youwen., DiBerto Jeffrey F., Zhou X Edward., Schmitz Gavin P., Yuan Qingning., Jain Manish K., Liu Weiyi., Melcher Karsten., Jiang Yi., Roth Bryan L., Xu H Eric.(2023). Structures of the entire human opioid receptor family. Cell, 186(2), 413-427.e17.(20230112,中国科学院上海药物研究所,徐华强、庄友文;美国北卡罗莱纳大学教堂山分校,Bryan L. Roth)
6. Fan Zhengxiao., Chang Jiarui., Liang Yilan., Zhu Hong., Zhang Chaoyi., Zheng Diyang., Wang Junying., Xu Ying., Li Qi-Jing., Hu Hailan.(2023). Neural mechanism underlying depressive-like state associated with social status loss.Cell, 186(3), 560-576.e17.(20230123,浙江大学,胡海岚)
9. Qin Ning., Li Lingyun., Ji Xu., Pereira Rui., Chen Yu., Yin Shile., Li Chaokun., Wan Xiaozhen., Qiu Danye., Jiang Junfeng., Luo Hao., Zhang Yueping., Dong Genlai., Zhang Yiming., Shi Shuobo., Jessen Henning J., Xia Jianye., Chen Yun., Larsson Christer., Tan Tianwei., Liu Zihe., Nielsen Jens.(2023). Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast. Cell, 186(4), 748-763.e15.(20230208,北京化工大学,Jens Nielsen、刘子鹤)
10. Gao Yina., Luo Xiu., Li Peipei., Li Zhaolong., Ye Feng., Liu Songqing., Gao Pu.(2023). Molecular basis of RADAR anti-phage supramolecular assemblies. Cell, 186(5), 999-1012.e20.(20230209,中科院生物物理研究所,高璞)
11. Chen Jing., Yang Xinglou., Si Haorui., Gong Qianchun., Que Tengcheng., Li Jing., Li Yang., Wu Chunguang., Zhang Wei., Chen Ying., Luo Yun., Zhu Yan., Li Bei., Luo Dongsheng., Hu Ben., Lin Haofeng., Jiang Rendi., Jiang Tingting., Li Qian., Liu Meiqin., Xie Shizhe., Su Jia., Zheng Xiaoshuang., Li Ang., Yao Yulin., Yang Yong., Chen Panyu., Wu Aiqiong., He Meihong., Lin Xinhua., Tong Yigang., Hu Yanling., Shi Zheng-Li., Zhou Peng.(2023). A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry. Cell, 186(4), 850-863.e16.(20230216,中国科学院武汉病毒研究所/广州实验室、周鹏;中国科学院武汉病毒所,石正丽;广西医科大学,胡艳玲;北京化工大学,童贻刚;复旦大学,林鑫华)
13. Qin Fangfei., Li Boyuan., Wang Hui., Ma Sihui., Li Jiaofeng., Liu Shanglin., Kong Linghao., Zheng Huangtao., Zhu Rongfeng., Han Yu., Yang Mingdong., Li Kai., Ji Xiong., Chen Peng R.(2023). Linking chromatin acylation mark-defined proteome and genome in living cells. Cell, 186(5), 1066-1085.e36.(20230302,北京大学,陈鹏、季雄)
14. Shao Changwei., Sun Shuai., Liu Kaiqiang., Wang Jiahao., Li Shuo., Liu Qun., Deagle Bruce E., Seim Inge., Biscontin Alberto., Wang Qian., Liu Xin., Kawaguchi So., Liu Yalin., Jarman Simon., Wang Yue., Wang Hong-Yan., Huang Guodong., Hu Jiang., Feng Bo., De PittàCristiano., Liu Shanshan., Wang Rui., Ma Kailong., Ying Yiping., Sales Gabrielle., Sun Tao., Wang Xinliang., Zhang Yaolei., Zhao Yunxia., Pan Shanshan., Hao Xiancai., Wang Yang., Xu Jiakun., Yue Bowen., Sun Yanxu., Zhang He., Xu Mengyang., Liu Yuyan., Jia Xiaodong., Zhu Jiancheng., Liu Shufang., Ruan Jue., Zhang Guojie., Yang Huanming., Xu Xun., Wang Jun., Zhao Xianyong., Meyer Bettina., Fan Guangyi.(2023). The enormous repetitive Antarctic krill genome reveals environmental adaptations and population insights.Cell, 186(6), 1279-1294.e19.(20230302,青岛华大基因研究院,范广益;University of Oldenburg,Bettina Meyer;中国水产科学研究院黄海水产研究所,邵长伟)
18. Wang Yanyan., Zhang Senxin., Yang Xinrui., Hwang Joyce K., Zhan Chuanzong., Lian Chaoyang., Wang Chong., Gui Tuantuan., Wang Binbin., Xie Xia., Dai Pengfei., Zhang Lu., Tian Ying., Zhang Huizhi., Han Chong., Cai Yanni., Hao Qian., Ye Xiaofei., Liu Xiaojing., Liu Jiaquan., Cao Zhiwei., Huang Shaohui., Song Jie., Pan-Hammarström Qiang., Zhao Yaofeng., Alt Frederick W., Zheng Xiaoqi., Da Lin-Tai., Yeap Leng-Siew., Meng Fei-Long.(2023). Mesoscale DNA feature in antibody-coding sequence facilitates somatic hypermutation. Cell, 186(10), 2193-2207.e19.(20230424,中国科学院分子细胞科学卓越创新中心,孟飞龙;上海交通大学,叶菱秀)
19. Zhai Jinglei., Xu Yanhong., Wan Haifeng., Yan Rui., Guo Jing., Skory Robin., Yan Long., Wu Xulun., Sun Fengyuan., Chen Gang., Zhao Wentao., Yu Kunyuan., Li Wei., Guo Fan., Plachta Nicolas., Wang Hongmei.(2023). Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture. Cell, 186(10), 2078-2091.e18.(20230511,中国科学院动物研究所,王红梅、郭帆、李伟;美国宾夕法尼亚大学,Nicolas Plachta)
20. Cao Duanfang., Ma Bingting., Cao Ziyi., Zhang Xinzheng., Xiang Ye.(2023). Structure of Semliki Forest virus in complex with its receptor VLDLR. Cell, 186(10), 2208-2218.e15.(20230424,清华大学,向烨;中国科学院生物物理所,章新政)
21. Gong Yandong., Bai Bing., Sun Nianqin., Ci Baiquan., Shao Honglian., Zhang Ting., Yao Hui., Zhang Youyue., Niu Yuyu., Liu Lizhong., Zhao Hu., Wu Hao., Zhang Lei., Wang Tianxiang., Li Shangang., Wei Yulei., Yu Yang., Ribeiro Orsi Ana Elisa., Liu Bing., Ji Weizhi., Wu Jun., Chen Yongchang., Tan Tao.(2023). Ex utero monkey embryogenesis from blastocyst to early organogenesis. Cell, 186(10), 2092-2110.e23.(20230511,昆明理工大学,谭韬、陈永昌、季维智;中国人民解放军总医院,刘兵;德州西南医学中心,吴军)
23. Zhao Zhifeng., Zhou Yiliang., Liu Bo., He Jing., Zhao Jiayin., Cai Yeyi., Fan Jingtao., Li Xinyang., Wang Zilin., Lu Zhi., Wu Jiamin., Qi Hai., Dai Qionghai.(2023). Two-photon synthetic aperture microscopy for minimally invasive fast 3D imaging of native subcellular behaviors in deep tissue. Cell, 186(11), 2475-2491.e22.(20230512,清华大学,戴琼海、吴嘉敏、祁海)
25. Zhou Lunni., Liu Haobin., Liu Siyu., Yang Xiaoyu., Dong Yue., Pan Yun., Xiao Zhuang., Zheng Beihong., Sun Yan., Huang Pengyu., Zhang Xixi., Hu Jin., Sun Rui., Feng Shan., Zhu Yi., Liu Mingxi., Gui Miao., Wu Jianping.(2023). Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Cell, 186(13), 2897-2910.e19.(20230608,西湖大学生,吴建平;浙江大学,桂淼;南京医科大学、刘明兮)
26. Deng Pujuan., Tan Shun-Qing., Yang Qi-Yu., Fu Liangzheng., Wu Yachao., Zhu Han-Zhou., Sun Lei., Bao Zhangbin., Lin Yi., Zhang Qiangfeng Cliff., Wang Haoyi., Wang Jia., Liu Jun-Jie Gogo.(2023). Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell, 186(13), 2865-2879.e20.(20230609,清华大学,刘俊杰、王家)
27. Chen Haiwei., Rosen Connor E., González-Hernández Jaime A., Song Deguang., Potempa Jan., Ring Aaron M., Palm Noah W.(2023). Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions. Cell, 186(14), 3095-3110.e19.(20230614,复旦大学,陈海威;耶鲁大学,Noah Palm)
结合条形码技术和下一代基因测序技术,将PRESTO-Tango技术升级为PRESTO-Salsa筛选平台(Parallel Receptor-ome Expression and Screening via Transcriptional Output-Salsa),在(96孔板)单孔中集成314个GPCR报告细胞系,用于“一对多”功能筛选。(Cell | 陈海威等开发PRESTO-Salsa筛选平台,初步绘制人体/人体细菌代谢物-GPCR作用图谱)
28. He Kaixin., Wan Tingting., Wang Decai., Hu Ji., Zhou Tingyue., Tao Wanyin., Wei Zheng., Lu Qiao., Zhou Rongbin., Tian Zhigang., Flavell Richard A., Zhu Shu.(2023). Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine. Cell, 186(14), 3033-3048.e20.(20230615,中国科学技术大学,朱书)
30. Li Hui., Wang Jinlong., Kuan Tung Ariel., Tang Bozeng., Feng Li., Wang Jiuyu., Cheng Zhi., Skłenar Jan., Derbyshire Paul., Hulin Michelle., Li Yufei., Zhai Yi., Hou Yingnan., Menke Frank L H., Wang Yanli., Ma Wenbo.(2023). Pathogen protein modularity enables elaborate mimicry of a host phosphatase.Cell, 186(15), 3196-3207.e17.(20230626,中国科学院生物物理研究所,王艳丽;英国塞恩斯伯里实验室,马文勃)
31. Zhuang Yanrong., Li Zhiyuan., Xiong Shiyue., Sun Chujie., Li Boya., Wu Shuangcheng Alivia., Lyu Jiali., Shi Xiang., Yang Liang., Chen Yutong., Bao Zhangbin., Li Xi., Sun Chuhanwen., Chen Yuling., Deng Haiteng., Li Tingting., Wu Qingfeng., Qi Ling., Huang Yue., Yang Xuerui., Lin Yi.(2023). Circadian clocks are modulated by compartmentalized oscillating translation. Cell, 186(15), 3245-3260.e23.(20230626,清华大学,吝易、杨雪瑞)
32. Huang Jiaying., Lin Qiupeng., Fei Hongyuan., He Zixin., Xu Hu., Li Yunjia., Qu Kunli., Han Peng., Gao Qiang., Li Boshu., Liu Guanwen., Zhang Lixiao., Hu Jiacheng., Zhang Rui., Zuo Erwei., Luo Yonglun., Ran Yidong., Qiu Jin-Long., Zhao Kevin Tianmeng., Gao Caixia.(2023). Discovery of deaminase functions by structure-based protein clustering. Cell, 186(15), 3182-3195.e14.(20230627,中国科学院遗传与发育生物学研究所,高彩霞)
34. Xiang Jie., Tao Youqi., Xia Yiyuan., Luo Shilin., Zhao Qinyue., Li Bowei., Zhang Xiaoqian., Sun Yunpeng., Xia Wencheng., Zhang Mingming., Kang Seong Su., Ahn Eun-Hee., Liu Xia., Xie Fang., Guan Yihui., Yang Jenny J., Bu Lihong., Wu Shengxi., Wang Xiaochuan., Cao Xuebing., Liu Cong., Zhang Zhentao., Li Dan., Ye Keqiang.(2023). Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies. Cell, 186(16), 3350-3367.e19.(20230707,深圳理工大学/中国科学院深圳先进技术研究院,叶克强;上海交通大学,李丹;武汉大学,张振涛)
35. Chen Ao., Sun Yidi., Lei Ying., Li Chao., Liao Sha., Meng Juan., Bai Yiqin., Liu Zhen., Liang Zhifeng., Zhu Zhiyong., Yuan Nini., Yang Hao., Wu Zihan., Lin Feng., Wang Kexin., Li Mei., Zhang Shuzhen., Yang Meisong., Fei Tianyi., Zhuang Zhenkun., Huang Yiming., Zhang Yong., Xu Yuanfang., Cui Luman., Zhang Ruiyi., Han Lei., Sun Xing., Chen Bichao., Li Wenjiao., Huangfu Baoqian., Ma Kailong., Ma Jianyun., Li Zhao., Lin Yikun., Wang He., Zhong Yanqing., Zhang Huifang., Yu Qian., Wang Yaqian., Liu Xing., Peng Jian., Liu Chuanyu., Chen Wei., Pan Wentao., An Yingjie., Xia Shihui., Lu Yanbing., Wang Mingli., Song Xinxiang., Liu Shuai., Wang Zhifeng., Gong Chun., Huang Xin., Yuan Yue., Zhao Yun., Chai Qinwen., Tan Xing., Liu Jianfeng., Zheng Mingyuan., Li Shengkang., Huang Yaling., Hong Yan., Huang Zirui., Li Min., Jin Mengmeng., Li Yan., Zhang Hui., Sun Suhong., Gao Li., Bai Yinqi., Cheng Mengnan., Hu Guohai., Liu Shiping., Wang Bo., Xiang Bin., Li Shuting., Li Huanhuan., Chen Mengni., Wang Shiwen., Li Minglong., Liu Weibin., Liu Xin., Zhao Qian., Lisby Michael., Wang Jing., Fang Jiao., Lin Yun., Xie Qing., Liu Zhen., He Jie., Xu Huatai., Huang Wei., Mulder Jan., Yang Huanming., Sun Yangang., Uhlen Mathias., Poo Muming., Wang Jian., Yao Jianhua., Wei Wu., Li Yuxiang., Shen Zhiming., Liu Longqi., Liu Zhiyong., Xu Xun., Li Chengyu.(2023). Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex. Cell, 186(17), 3726-3743.e24.(20230712,中国科学院脑科学与智能技术卓越创新中心,李澄宇、刘志勇、孙怡迪、沈志明;华大生命科学研究院,徐讯、刘龙奇、黎宇翔;临港实验室研究员,魏武;腾讯AI Lab,姚建华)
36. Wang Chaolong., Wang Jian., Lu Jiayu., Xiong Yehui., Zhao Zhigang., Yu Xiaowen., Zheng Xiaoming., Li Jing., Lin Qibing., Ren Yulong., Hu Yang., He Xiaodong., Li Chao., Zeng Yonglun., Miao Rong., Guo Mali., Zhang Bosen., Zhu Ying., Zhang Yunhui., Tang Weijie., Wang Yunlong., Hao Benyuan., Wang Qiming., Cheng Siqi., He Xiaojuan., Yao Bowen., Gao Junwen., Zhu Xufei., Yu Hao., Wang Yong., Sun Yan., Zhou Chunlei., Dong Hui., Ma Xiaoding., Guo Xiuping., Liu Xi., Tian Yunlu., Liu Shijia., Wang Chunming., Cheng Zhijun., Jiang Ling., Zhou Jiawu., Guo Huishan., Jiang Liwen., Tao Dayun., Chai Jijie., Zhang Wei., Wang Haiyang., Wu Chuanyin., Wan Jianmin.(2023). A natural gene drive system confers reproductive isolation in rice. Cell, 186(17), 3577-3592.e18.(20230726,南京农业大学,万建民;中国农业科学院作物科学研究所,吴传银、王海洋)
37. Meng Jiang-Guo., Xu Yin-Jiao., Wang Wei-Qi., Yang Fei., Chen Shu-Yan., Jia Peng-Fei., Yang Wei-Cai., Li Hong-Ju.(2023). Central-cell-produced attractants control fertilization recovery. Cell, 186(17), 3593-3605.e12.(20230728,中国科学院遗传与发育生物学研究所,李红菊)
38. Hu Ruoyang., Li Xuedong., Hu Yong., Zhang Runjie., Lv Qiang., Zhang Min., Sheng Xianyong., Zhao Feng., Chen Zhijia., Ding Yuhan., Yuan Huan., Wu Xiaofeng., Xing Shuang., Yan Xiaoyu., Bao Fang., Wan Ping., Xiao Lihong., Wang Xiaoqin., Xiao Wei., Decker Eva L., van Gessel Nico., Renault Hugues., Wiedemann Gertrud., Horst Nelly A., Haas Fabian B., Wilhelmsson Per K I., Ullrich Kristian K., Neumann Eva., Lv Bin., Liang Chengzhi., Du Huilong., Lu Hongwei., Gao Qiang., Cheng Zhukuan., You Hanli., Xin Peiyong., Chu Jinfang., Huang Chien-Hsun., Liu Yang., Dong Shanshan., Zhang Liangsheng., Chen Fei., Deng Lei., Duan Fuzhou., Zhao Wenji., Li Kai., Li Zhongfeng., Li Xingru., Cui Hengjian., Zhang Yong E., Ma Chuan., Zhu Ruiliang., Jia Yu., Wang Meizhi., Hasebe Mitsuyasu., Fu Jinzhong., Goffinet Bernard., Ma Hong., Rensing Stefan A., Reski Ralf., He Yikun.(2023). Adaptive evolution of the enigmatic Takakia now facing climate change in Tibet. Cell, 186(17), 3558-3576.e17.(20230809,首都师范大学,何奕騉;德国弗莱堡大学,Ralf Reski)
揭示了有植物活化石之称的藻苔在青藏高原的生存法则。
39. Tang Fei., Li Jinhu., Qi Lu., Liu Dongfang., Bo Yufei., Qin Shishang., Miao Yuhui., Yu Kezhuo., Hou Wenhong., Li Jianan., Peng Jirun., Tian Zhigang., Zhu Linnan., Peng Hui., Wang Dongfang., Zhang Zemin.(2023). A pan-cancer single-cell panorama of human natural killer cells. Cell, 186(19), 4235-4251.e20.(20230821,北京大学,张泽民;中国科学技术大学,彭慧)
40. Sun Honglei., Li Han., Tong Qi., Han Qiqi., Liu Jiyu., Yu Haili., Song Hao., Qi Jianxun., Li Jiaqi., Yang Jizhe., Lan Riguo., Deng Guojing., Chang Haoyu., Qu Yajin., Pu Juan., Sun Yipeng., Lan Yu., Wang Dayan., Shi Yi., Liu William J., Chang Kin-Chow., Gao George F., Liu Jinhua.(2023). Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets.Cell, 186(19), 4074-4084.e11.(20230904,中国农业大学,刘金华;中国科学院微生物研究所,高福)
41. Yang Min., Ong Jennie., Meng Fanju., Zhang Feixiang., Shen Hui., Kitt Kerstin., Liu Tengfei., Tao Wei., Du Peng.(2023). Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells. Cell, 186(20), 4271-4288.e24.(20230911,北京大学,杜鹏)
42. Wang Zeshuai., Wu Zhisheng., Wang Hao., Feng Ruoqing., Wang Guanlin., Li Muxi., Wang Shuang-Yin., Chen Xiaoyan., Su Yiyi., Wang Jun., Zhang Weiwen., Bao Yuzhou., Lan Zhenwei., Song Zhuo., Wang Yiheng., Luo Xianyang., Zhao Lingyu., Hou Anli., Tian Shuye., Gao Hongliang., Miao Wenbin., Liu Yingyu., Wang Huilin., Yin Cui., Ji Zhi-Liang., Feng Mingqian., Liu Hongkun., Diao Lianghui., Amit Ido., Chen Yun., Zeng Yong., Ginhoux Florent., Wu Xueqing., Zhu Yuanfang., Li Hanjie.(2023). An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development. Cell, 186(20), 4454-4471.e19.(20230912,中国科学院深圳先进技术研究院,李汉杰;深圳市宝安区妇幼保健院,朱元方;深圳大学总医院,吴雪清;上海交通大学,Florent Ginhoux;复旦大学;王冠琳)
43. Chen Yan-Mei., Hu Shu-Jian., Lin Xian-Dan., Tian Jun-Hua., Lv Jia-Xin., Wang Miao-Ruo., Luo Xiu-Qi., Pei Yuan-Yuan., Hu Rui-Xue., Song Zhi-Gang., Holmes Edward C., Zhang Yong-Zhen.(2023). Host traits shape virome composition and virus transmission in wild small mammals. Cell, 186(21), 4662-4675.e12.(20230920,复旦大学,张永振)
44. Chen Jiayue., Yu Renbo., Li Na., Deng Zhaoguo., Zhang Xinxin., Zhao Yaran., Qu Chengfu., Yuan Yanfang., Pan Zhexian., Zhou Yangyang., Li Kunlun., Wang Jiajun., Chen Zhiren., Wang Xiaoyi., Wang Xiaolian., He Shu-Nan., Dong Juan., Deng Xing Wang., Chen Haodong.(2023). Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants. Cell, 186(22), 4788-4802.e15.(20230922,清华大学,陈浩东)
46. Lan Zijun., Song Zihan., Wang Zhijuan., Li Ling., Liu Yiqun., Zhi Shuaihua., Wang Ruihan., Wang Jizong., Li Qiyun., Bleckmann Andrea., Zhang Li., Dresselhaus Thomas., Dong Juan., Gu Hongya., Zhong Sheng., Qu Li-Jia.(2023). Antagonistic RALF peptides control an intergeneric hybridization barrier on Brassicaceae stigmas. Cell, 186(22), 4773-4787.e12.(20231007,北京大学,瞿礼嘉,钟声)
47. Chen Yefei., Hong Zexuan., Wang Jingyi., Liu Kunlin., Liu Jing., Lin Jianbang., Feng Shijing., Zhang Tianhui., Shan Liang., Liu Taian., Guo Pinyue., Lin Yunping., Li Tian., Chen Qian., Jiang Xiaodan., Li Anan., Li Xiang., Li Yuantao., Wilde Jonathan J., Bao Jin., Dai Ji., Lu Zhonghua.(2023). Circuit-specific gene therapy reverses core symptoms in a primate Parkinson's disease model. Cell, 186(24), 5394-5410.e18.(20231102,中国科学院深圳先进技术研究院,路中华、戴辑、鲍进)
48. Cao Jing., Li Wenjuan., Li Jie., Mazid Md Abdul., Li Chunyang., Jiang Yu., Jia Wenqi., Wu Liang., Liao Zhaodi., Sun Shiyu., Song Weixiang., Fu Jiqiang., Wang Yan., Lu Yong., Xu Yuting., Nie Yanhong., Bian Xinyan., Gao Changshan., Zhang Xiaotong., Zhang Liansheng., Shang Shenshen., Li Yunpan., Fu Lixin., Liu Hao., Lai Junjian., Wang Yang., Yuan Yue., Jin Xin., Li Yan., Liu Chuanyu., Lai Yiwei., Shi Xuyang., Maxwell Patrick H., Xu Xun., Liu Longqi., Poo Muming., Wang Xiaolong., Sun Qiang., Esteban Miguel A., Liu Zhen.(2023). Live birth of chimeric monkey with high contribution from embryonic stem cells. Cell, 186(23), 4996-5014.e24.(20231109,中国科学院脑科学与智能技术卓越创新中心,刘真、孙强;中国科学院广州生物医药与健康研究院,Miguel A. Esteban)
49. Shang Pan., Rong Naikang., Jiang Jing-Jing., Cheng Jie., Zhang Ming-Hui., Kang Dongwei., Qi Lei., Guo Lulu., Yang Gong-Ming., Liu Qun., Zhou Zhenzhen., Li Xiao-Bing., Zhu Kong-Kai., Meng Qing-Biao., Han Xiang., Yan Wenqi., Kong Yalei., Yang Lejin., Wang Xiaohui., Lei Dapeng., Feng Xin., Liu Xinyong., Yu Xiao., Wang Yue., Li Qian., Shao Zhen-Hua., Yang Fan., Sun Jin-Peng.(2023). Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186(24), 5347-5362.e24.(20231113,山东大学,孙金鹏、杨帆;四川大学,邵振华;上海交通大学医学院,李乾;山东第一医科大学,王越)
50. Gao Shuai., Yao Xia., Chen Jiaofeng., Huang Gaoxingyu., Fan Xiao., Xue Lingfeng., Li Zhangqiang., Wu Tong., Zheng Yupeng., Huang Jian., Jin Xueqin., Wang Yan., Wang Zhifei., Yu Yong., Liu Lei., Pan Xiaojing., Song Chen., Yan Nieng.(2023). Structural basis for human Ca1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186(24), 5363-5374.e16.(20231115,清华大学/深圳医学科学院,颜宁;北京大学,宋晨;武汉大学,高帅)
揭示了自由状态、多种药物结合、多肽毒素结合的钙离子通道Cav1.2的高分辨结构。
51. Yu Yongqiang., Tang Wenxin., Lin Wenwei., Li Wei., Zhou Xiang., Li Ying., Chen Rong., Zheng Rui., Qin Guochen., Cao Wenhan., Pérez-Henríquez Patricio., Huang Rongfeng., Ma Jun., Qiu Qiqi., Xu Ziwei., Zou Ailing., Lin Juncheng., Jiang Liwen., Xu Tongda., Yang Zhenbiao.(2023). ABLs and TMKs are co-receptors for extracellular auxin. Cell, 186(25), 5457-5471.e17.(20231117,福建农林大学,徐通达、杨贞标)
该研究报道了两个新的质外体定位的生长素结合蛋白,ABL1(ABP1-like protein 1)和ABL2,与生长素结合蛋白ABP1具有相似结构,在细胞膜上形成ABP1/ABLs-TMK生长素共受体感受并传递胞外生长素信号,调控植物生长和发育的分子机制。
52. Sang Di., Lin Keteng., Yang Yini., Ran Guangdi., Li Bohan., Chen Chen., Li Qi., Ma Yan., Lu Lihui., Cui Xi-Yang., Liu Zhibo., Lv Sheng-Qing., Luo Minmin., Liu Qinghua., Li Yulong., Zhang Eric Erquan.(2023). Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals. Cell, 186(25), 5500-5516.e21.(20231127,北京生命科学研究所/清华大学,张二荃)
55. Li Yanxin., Li Zhongqiu., Wang Changliang., Yang Min., He Ziqing., Wang Feiyang., Zhang Yuehong., Li Rong., Gong Yunxia., Wang Binhong., Fan Baoguang., Wang Chunyue., Chen Lei., Li Hong., Shi Peifu., Wang Nana., Wei Zhifeng., Wang Yan-Ling., Jin Lei., Du Peng., Dong Ji., Jiao Jianwei.(2023). Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain. Cell, 186(26), 5892-5909.e22.(20231212,中国科学院动物研究所,焦建伟;广州国家实验室,董骥;北京大学,杜鹏、靳蕾)
该研究将单细胞测序(scRNA-seq)和单细胞空间转录组技术(scStereo-seq)相结合,首次解析了迄今为止跨时间点最广(GW6-GW23)、面积最大(最大4cm x 3cm)的人脑多区域时空发育转录组图谱。该研究鉴定并呈现了发育早期具有特定空间分布特点的异质性放射状胶质细胞亚型,揭示了这些异质性放射状胶质细胞有助于随后不同脑区神经元的特化,同时发现胶质细胞和神经元互作也会促进神经元的区域特化。(专家点评Cell丨焦建伟/董骥/杜鹏/靳蕾合作解析迄今最全面的人脑多区域时空发育图谱及规律)
56. Liao Yu-Ying., Zhang Huibing., Shen Qingya., Cai Chenxi., Ding Yu., Shen Dan-Dan., Guo Jia., Qin Jiao., Dong Yingjun., Zhang Yan., Li Xiao-Ming.(2023). Snapshot of the cannabinoid receptor 1-arrestin complex unravels the biased signaling mechanism. Cell,186(26), 5784-5797.e17.(20231214,浙江大学,李晓明、张岩)
57. Chen Yuping., Wu Jinhuan., Zhai Linhui., Zhang Tingting., Yin Hui., Gao Huanyao., Zhao Fei., Wang Zhe., Yang Xiaoning., Jin Mingpeng., Huang Bingsong., Ding Xin., Li Rui., Yang Jie., He Yiming., Wang Qianwen., Wang Weibin., Kloeber Jake A., Li Yunxuan., Hao Bingbing., Zhang Yuanyuan., Wang Jiadong., Tan Minjia., Li Ke., Wang Ping., Lou Zhenkun., Yuan Jian.(2023). Metabolic regulation of homologous recombination repair by MRE11 lactylation. Cell.(20231220,同济大学,袁健)
59. Wang Dongfang., Liu Baolin., Zhang Zemin.(2023). Accelerating the understanding of cancer biology through the lens of genomics. Cell, 186(8), 1755-1771.(20230413,北京大学,张泽民)